Molecular NGS Variant Interpretation & Structured Diagnostic Delivery Pipeline
Convert complex raw genomic VCF data into physician-ready clinical reports with automated ACMG/AMP variant classifications, FDA-approved therapeutic matching, and discrete EHR delivery.
Next-Generation Sequencing (NGS) gene panels for somatic oncology, hereditary cancer risk, and pharmacogenomics (PGx) generate massive datasets containing hundreds of genetic variants. Manually cross-referencing raw variant call format (VCF) files against ClinVar, COSMIC, gnomAD, and published clinical trials creates an unsustainable bioinformatic bottleneck. TravaLabs delivers a cloud-native molecular interpretation pipeline that annotates variants in seconds according to ACMG/AMP and CAP guidelines, matches actionable mutations to FDA-approved targeted therapies, and pushes structured genomic findings directly into oncologists EHRs.
Key results
- < 60 Sec — VCF Annotation & Tier Classification
- 80% — Bioinformatic Labor Reduction
- 100% — ACMG / AMP Guideline Alignment
- Real-Time — ClinicalTrials.gov Match Sync
Core capabilities
- Automated ACMG / AMP 5-Tier Classification — Algorithms apply standard ACMG/AMP evidence criteria (PVS1, PS1–4, PM1–6) to classify variants as Pathogenic, Likely Pathogenic, VUS, Likely Benign, or Benign.
- Actionable FDA Drug & Clinical Trial Matching — Instantly matches Tier I/II actionable somatic mutations to FDA-approved targeted therapies (e.g. EGFR, KRAS, BRAF, NTRK) and actively recruiting clinical trials.
- Executive Oncologist Summary Dashboard — Condenses complex multi-gene panels into an authoritative 2-page executive summary highlighting top therapeutic vulnerabilities and resistance mutations.
- FHIR STU2 Discrete Genomic EHR Transmission — Transmits discrete genomic variants, copy number variations (CNV), and microsatellite instability (MSI) status directly into Epic and Cerner EHR records.
Deployment roadmap
- Day 1–10: Gene Panel & Filter Configuration — Configure specific targeted gene panels (e.g. 50-gene solid tumor, 500-gene comprehensive panel), set variant allele frequency (VAF) and read depth cutoffs.
- Day 11–20: Knowledgebase Integration & Report Design — Calibrate automated ACMG/AMP rule scoring, link hospital institutional clinical trials, and format oncologist-friendly executive summary reports.
- Day 21–30: LIMS / EHR Validation & Clinical Launch — Validate automated interpretations against 100 previously sequenced clinical controls and launch automated discrete transmission to EHR charts.
Frequently asked questions
Does TravaLabs support somatic oncology as well as germline hereditary testing?
Yes. TravaLabs includes separate validation pipelines for somatic cancer profiling (using the AMP/ASCO/CAP 4-tier system) and germline inherited disease (using ACMG/AMP guidelines).
How frequently are clinical drug indications and trial registries updated?
Our genomic knowledgebase updates continuously in real time, synchronizing with FDA oncology approvals, NCCN guidelines, and ClinicalTrials.gov daily.